Chemical Biology and Biocatalysis Group (CBB)

Department of Biocatalysis

Institute of Catalysis and Petrochemistry (ICP-CSIC)

About Us

The Chemical Biology and Biocatalysis research group at the department of Biocatalysis, Institute of Catalysis and Petrochemistry, The Spanish National Research Council conducts research on novel biological catalysis study and design, and their application by sustainable chemical processes in different important areas: Bioremediation, Energy, Fine Chemistry, Medicinal Chemistry, Nanobiomaterials.


Protein Chemistry

  • Site-specific chemical modification of proteins (peptides, polymers, small molecules)
  • Synthesis of new semisynthetic enzymes
  • Synthesis of new artificial metalloenzymes (organometallic complexes, metals)
  • Site-specific protocols for purification andΒ immobilization of enzymes


  • Design and Synthesis of new Nanobiohybrids
  • Biosynthesis of novel metal ultra-small Nanoparticles and Nanostructures (Pd, Ag, Au, Cu, Fe, Zn, Mn, Mg, Co)
  • Application of novel metal biohybrids as Nanocatalysts: Organic synthesis, Environmental remediation, Biomedicine, Energy, Health


  • Development of new building blocks in Carbohydrate chemistry
  • Synthesis of relevant oligosaccharides
  • Synthesis of novel glycopolymers and glycoconjugates
  • Synthesis of glycosidases inhibitors
  • Synthesis of novel bioadhesives


  • Designed biomolecules in infectious diseases,Β eg. Hepatitis C virus
  • Role of tyrosinase in medicinal chemistry
  • Novel antiviral agents (e.g against Coronaviruses, Rhinoviruses, Phages, etc.)
  • Novel antimicrobial agents (e.g. bacteria, fungus, etc.)

New references related to the project

Scientific Papers

Palomo, J.M. Synthesis of Regioselective Carbohydrates Building Blocks by Heterogeneous Engineered Biocatalysts. General Chemistry. 2022, 8 (3-4): 220009-220009. Β  DOI: 10.21127/yaoyigc20220009.


Prof. Dr. Jose M. Palomo, Head of the group, e-mail:Β

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